Flecainide and elevated liver enzymes in α1-antitrypsin deficiency

نویسندگان

  • David J.A. Jenkins
  • Michael Freeman
  • Iqwal Mangat
  • Koruba Srichaikul
  • Viranda H. Jayalath
  • Dorothea Faulkner
  • John L. Sievenpiper
  • Cyril W.C. Kendall
  • Alexander Romaschin
  • Young-In Kim
  • Paul Dorian
چکیده

deficiency David J.A. Jenkins, MD, PhD, FRCP, Michael Freeman, MD, FRCPC, Iqwal Mangat, MD, FRCPC, Koruba Srichaikul, MD, MSc, Viranda H. Jayalath, MSc, Dorothea Faulkner, RD, PhD, John L. Sievenpiper, MD, PhD, FRCPC, Cyril W.C. Kendall, PhD, Alexander Romaschin, PhD, Young-In Kim, MD, FRCPC, Paul Dorian, MD, FRCPC, FHRS From the Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, and Clinical Nutrition and Risk Factor Modification Center, St Michael's Hospital, Toronto, Ontario, Canada, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, Ontario, Canada, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Division of Cardiology, Department of Cardiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Department of Clinical Chemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, Division of Gastroenterology, Department of Medicine, University of Toronto and St Michael's Hospital, Toronto, Canada, Li Ka Shing Knowledge Institute and Keenan Research Centre for Biomedical Science, St Michael’s Hospital, Toronto, Ontario, Canada, and Department of Family and Community Medicine, St Michael's Hospital and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Alpha- 1 Antitrypsin Deficiency in Children: Pulmonary Involvement

Introduction: α1-antitrypsin deficiency (α1-ATD) is one of the most common genetic disorders in white race, a usual cause of liver disease in children, and hepatopulmonary involvement in children and adult. The aim of this case description is presenting a child with early lung disease without liver parenchymal disorder. Case presentation: We describe a 13 year old boy because of exertional dysp...

متن کامل

Augmentation treatment for α1 antitrypsin deficiency.

www.thelancet.com Published online May 28, 2015 http://dx.doi.org/10.1016/S0140-6736(15)60036-8 1 α1 antitrypsin is a serine antiprotease secreted by the liver. Its main function is inhibition of neutrophil elastase, a non-specifi c protease released by activated or dying neutrophils. In individuals with healthy concentrations of α1 antitrypsin, the fragile alveolar structures of the lung paren...

متن کامل

-antitrypsin misfolding

We were all taught that proteins have to fold correctly to be active and that the primary sequence of amino acids acts as the ’blueprint‘ for successful, productive folding. in recent years, we have also learnt how sensitive that blueprint is to change. For example, a single amino-acid change in the protein sequence, or a subtle change in temperature at which folding takes place, can lead to th...

متن کامل

Inflammatory markers in chronic obstructive pulmonary disease patients with different α1 antitrypsin genotypes

INTRODUCTION Chronic obstructive pulmonary disease (COPD) has been recently defined as a systemic pulmonary inflammatory disease, and congenital α1 antitrypsin deficiency is one of the well-established genetic risk factors for chronic obstructive pulmonary disease. The aim of our study was to evaluate the possible associations of α1 antitrypsin with inflammatory markers - CRP, sCD14, TNF-α, sTN...

متن کامل

Diagnosing α1-antitrypsin deficiency: how to improve the current algorithm.

Over the past 10-15 years, the diagnosis of α1-antitrypsin deficiency (AATD) has markedly improved as a result of increasing awareness and the publication of diagnostic recommendations by the American Thoracic Society (ATS)/European Respiratory Society (ERS). Nevertheless, the condition remains substantially underdiagnosed. Furthermore, when AATD is diagnosed there is a delay before treatment i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2016